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Bicra BRD4 interacting chromatin remodeling complex associated protein [ Mus musculus (house mouse) ]

Gene ID: 243842, updated on 30-Apr-2024

Summary

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Official Symbol
Bicraprovided by MGI
Official Full Name
BRD4 interacting chromatin remodeling complex associated proteinprovided by MGI
Primary source
MGI:MGI:2154263
See related
Ensembl:ENSMUSG00000070808 AllianceGenome:MGI:2154263
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gltscr1
Summary
Predicted to enable transcription regulator activator activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome. Orthologous to human BICRA (BRD4 interacting chromatin remodeling complex associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 18.0), spleen adult (RPKM 18.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A2; 7 8.67 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15704596..15785047, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (15970671..16048146, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2814 Neighboring gene small nucleolar RNA, C/D box 23 Neighboring gene NOP53 ribosome biogenesis factor Neighboring gene predicted gene, 24576 Neighboring gene EH-domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11342 Neighboring gene STARR-seq mESC enhancer starr_18118 Neighboring gene STARR-seq mESC enhancer starr_18119 Neighboring gene predicted gene, 38948 Neighboring gene RIKEN cDNA 2010004M13 gene Neighboring gene STARR-positive B cell enhancer ABC_E6514 Neighboring gene STARR-positive B cell enhancer ABC_E1078 Neighboring gene STARR-positive B cell enhancer ABC_E4897 Neighboring gene STARR-positive B cell enhancer ABC_E2815 Neighboring gene zinc finger protein 541 Neighboring gene STARR-seq mESC enhancer starr_18124 Neighboring gene STARR-positive B cell enhancer ABC_E541 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription. Han F, et al. Angiogenesis, 2023 May. PMID 36745292, Free PMC Article
  2. The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice. Hong HK, et al. Proc Natl Acad Sci U S A, 2004 Feb 10. PMID 14755058, Free PMC Article
  3. Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7. Chae TH, et al. Mamm Genome, 2002 May. PMID 12016511
  4. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Gatchalian J, et al. Nat Commun, 2018 Dec 3. PMID 30510198, Free PMC Article
  5. An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Ho L, et al. Proc Natl Acad Sci U S A, 2009 Mar 31. PMID 19279220, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription.
    Title: Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription regulator activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of GBAF complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BRD4-interacting chromatin-remodeling complex-associated protein
Names
glioma tumor suppressor candidate region gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081418.1 → NP_001074887.1  BRD4-interacting chromatin-remodeling complex-associated protein

    See identical proteins and their annotated locations for NP_001074887.1

    Status: PROVISIONAL

    Source sequence(s)
    AC148990
    Consensus CDS
    CCDS39780.1
    UniProtKB/Swiss-Prot
    F8VPZ9
    Related
    ENSMUSP00000092416.4, ENSMUST00000094821.4
    Conserved Domains (3) summary
    PHA03247
    Location:321 → 935
    PHA03247; large tegument protein UL36; Provisional
    PRK14086
    Location:1383 → 1561
    dnaA; chromosomal replication initiator protein DnaA
    pfam15249
    Location:1101 → 1202
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    15704596..15785047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242555.2 → XP_030098415.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:299 → 858
    PHA03247; large tegument protein UL36; Provisional
    PRK14086
    Location:1302 → 1480
    dnaA; chromosomal replication initiator protein DnaA
    pfam15249
    Location:1020 → 1121
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  2. XM_006539918.5 → XP_006539981.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:299 → 913
    PHA03247; large tegument protein UL36; Provisional
    PRK14086
    Location:1361 → 1539
    dnaA; chromosomal replication initiator protein DnaA
    pfam15249
    Location:1079 → 1180
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  3. XM_011250559.4 → XP_011248861.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X3

    Conserved Domains (3) summary
    PHA03247
    Location:321 → 880
    PHA03247; large tegument protein UL36; Provisional
    PRK14086
    Location:1324 → 1502
    dnaA; chromosomal replication initiator protein DnaA
    pfam15249
    Location:1042 → 1143
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  4. XM_006539917.5 → XP_006539980.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006539980.1

    UniProtKB/Swiss-Prot
    F8VPZ9
    Related
    ENSMUSP00000148012.2, ENSMUST00000210781.2
    Conserved Domains (3) summary
    PHA03247
    Location:321 → 935
    PHA03247; large tegument protein UL36; Provisional
    PRK14086
    Location:1383 → 1561
    dnaA; chromosomal replication initiator protein DnaA
    pfam15249
    Location:1101 → 1202
    GLTSCR1; Conserved region of unknown function on GLTSCR protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F8VPZ9.1 GenPept UniProtKB/Swiss-Prot:F8VPZ9

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